張大慈的個人資料 - 清華大學生命科學院學士班

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姓名	張大慈
個人網站	http://life.nthu.edu.tw/~labcmdt/

類別	專任師資
職稱	教授
單位別	分子與細胞生物研究所 / 生命科學系 / 學士班
授課領域	基因工程、生物有機化學、生物資訊
研究專長	蛋白質工程、醣生物醫學
實驗室	分子生物學實驗 /

期刊論文一覽
年度	著作	著作人
2012	Hung, S.-C., Lu, X.-A., Lee, J.-C., Chang, M. D.-T., Fang, S.-l., Fan, T.-c., Zulueta, M. M. L., Zhong, Y.-Q.,2012,Synthesis of heparin oligosaccharides and their interaction with eosinophil-derived neurotoxin.,Organic & Biomolecular Chemistry,10,4,pp760-772 (SCI)	張大慈
2011	Chuang, C.S., Pai, T.W., Hu, C.H., Tzou, W.S., Chang, M.D.T., Chang, H.T. and Chen, C.C,2011,Functional pathway mapping analysis for hypoxia-inducible factors,BMC Systems Biology ,5,S1,ppS3- (SCI)	張大慈
2011	Chou, W.-Y., Pai, T.-W., Jiang, T.-Y., Chou, W.-I., Tang, C.-Y., Chang, M. D.-T.,2011,Hydrophilic aromatic residue correlation and structure modeling for carbohydrate binding modules,PloS ONE,6, (SCI)	張大慈
2011	Weng, S.-L., Chang, S.-J., Cheng, Y.-C., Wang, H.-Y., Wang, T.-Y., Chang, M. D.-T., Wang, H.-W. ,2011,Comparative transcriptome analysis reveals a fetus origin of cord blood mesenchymal stem cells and novel fetal surface antigens for non-invasive prenatal diagnosis,Taiwanese Journal of Obstetrics and Gynecology,50,4,pp447-457 (SCI)	張大慈
2011	Chang, S.-J., Weng, S.-L., Hsieh, J.-Y., Wang, T.-Y., Chang, M. D.-T., Wang, H.-W.,2011,MicroRNA-34a modulates genes involved in cellular motility and oxidative phosphorylation in neuronal precursors derived from human umbilical cord mesenchymal stem cells,BMC Genomics, (SCI)	張大慈
2010	Lin, Y.M., Wu, S.J., Chang, T.W., Wang, C.F., Suen, C.S., Hwang, M.J., Chang, M.D.T., Chen, Y.T. and Liao, Y.D,2010,Outer Membrane Protein I of Pseudomonas aeruginosa Is a Target of Cationic Antimicrobial Peptide/Protein,Journal of Biological Chemistry,285,12,pp8985-8994 (SCI)	張大慈
2010	Chou, W.Y., Chou, W.I., Pai, T.W., Lin, S.C., Jiang, T.Y., Tang, C.Y. and Chang, M.D.T,2010,Feature-incorporated alignment based ligand-binding residue prediction for carbohydrate-binding modules,Bioinformatics,26,8,pp1022-1028 (SCI)	張大慈
2010	Chen, J. C., Uang, B.J., Lyu, P.C., Chang, J.Y., Liu, K.J., Kuo, C.C., Hsieh, H.P., Wang, H.C., Cheng, C.S., Chang, Y.H., Chang, M.D.T., Chang, W.S.W. and Lin, C.C.,2010,Design and Synthesis of alpha-Ketoamides as Cathepsin S Inhibitors with Potential Applications against Tumor Invasion and Angiogenesis,Journal of Medicinal Chemistry*,53,11,pp4545-4549 (SCI)	張大慈
2010	Chang, K.C., Lo, C.W., Fan, T.C., Chang, M.D.T., Shu, C.W., Chang, C.H., Chung, C.T., Fang, S.L., Chao, C.C., Tsai, J.J. and Lai, Y.K,2010,TNF-alpha Mediates Eosinophil Cationic Protein-induced Apoptosis in BEAS-2B Cells,BMC Cell Biology,11,pp6- (SCI)	張大慈
2010	Chang, H.T., Tseng, L.J., Hung, T.J., Kao, B.T., Lin, W.Y., Fan, T.C., Chang, M.D.T. and Pai, T.W,2010,Inhibition of the interactions between eosinophil cationic protein and airway epithelial cells by traditional Chinese herbs,BMC Systems Biology,4,S2,ppS8- (SCI)	張大慈
2009	Wang, T.Y., Chang, S.J., Chang, M.D.T. and Wang, H.W,2009,Unique biological properties and application potentials of CD34(+) CD38(-) stem cells from various sources,Taiwanese Journal of Obstetrics & Gynecology,48,4,pp356-369	張大慈
2009	Wang, H.Y., Ho, P.C., Lan, C.Y. and Chang, M.D.T,2009,Transcriptional Regulation of Human Eosinophil RNase2 by the Liver-Enriched Hepatocyte Nuclear Factor 4,Journal of Cellular Biochemistry,106,2,pp317-326 (SCI)	張大慈
2009	Lo, C.W., Chang, Y.S., Chao, C.C., Chang, M.D.T., Chang, K.C. and Lai, Y.K,2009,Control Mechanisms of Differential Translation of Hsp90 Isoforms in 9L Rat Gliosarcoma Cells,Journal of Cellular Biochemistry,107,3,pp418-427 (SCI)	張大慈
2009	Lin, S.C., Lin, I.P., Chou, W.I., Hsieh, C.A., Liu, S.H., Huang, R.Y., Sheu, C.C. and Chang, M.D.T.,2009,CBM21 starch-binding domain: A new purification tag for recombinant protein engineering,Protein Expression and Purification,65,2,pp261-266 (SCI)	張大慈
2009	Huang, Y.F., Chang, M.D.T. and Shieh, S.Y,2009,TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18,Molecular and Cellular Biology ,29,11,pp2935-2944 (SCI)	張大慈
2009	Chen, G.Y., Chen, C.Y., Chang, M.D.T., Matsuura, Y. and Hu, Y.C,2009,Concanavalin A Affinity Chromatography for Efficient Baculovirus Purification,Biotechnology Progress J.,25,6,pp1669-1677 (SCI)	張大慈
2009	Chang, S.J., Wang, T.Y., Tsai, C.Y., Hu, T.F., Chang, M.D.T. and Wang, H.W.,2009,Increased epithelial stem cell traits in advanced endometrial endometrioid carcinoma,BMC Genomics,10,pp613- (SCI)	張大慈
2008	Yen, C.N., Lin, Y.R., Chang, M.D.T., Tien, C.W., Wu, Y.C., Liao, C.J. and Hu, Y.C,2008,Use of porous alginate sponges for substantial chondrocyte expansion and matrix production: Effects of seeding density,Biotechnology Progress,24,2,pp452-457 (SCI)	張大慈
2008	Tung, J.Y., Chang, M.D.T., Chou, W.I., Liu, Y.Y., Yeh, Y.H., Chang, F.Y., Lin, S.C., Qiu, Z.L. and Sun, Y.J,2008,Crystal structures of the starch-binding domain from Rhizopus oryzae glucoamylase reveal a polysaccharide-binding path,Biochemical Journal,416,pp27-36 (SCI)	張大慈
2008	Shu, C.V., Sun, F.C., Cho, J.H., Lin, C.C., Liu, P.F., Chen, P.Y., Chang, M.D.T., Fu, H.W. and Lai, Y.K,2008,GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis,Journal of Cellular Physiology,215,3,pp627-635 (SCI)	張大慈
2008	Liu, W.T., Lin, S.C., Chou, W.I., Liu, T.H., Pan, R.L., Tzou, D.L., Hua, T.E. and Chang, M.D.T,2008,Identification and characterization of a novel fibril forming peptide in fungal starch binding domain,Biochemical and Biophysical Research Communications,377,3,pp966-970 (SCI)	張大慈
2008	Huang, R.Y., Chang, H.T., Lan, C.Y., Pai, T.W., Wu, C.N., Ling, C.M. and Chang, M.D.T,2008,Development and evaluation of a sensitive enzyme-linked oligonucleotide-sorbent assay for detection of polymerase chain reaction-amplified hepatitis C virus of genotypes 1-6,Journal of Virological Methods,151,2,pp211-216 (SCI)	張大慈
2008	Fan, T.C., Fang, S.L., Hwang, C.S., Hsu, C.Y., Lu, X.A., Hung, S.C., Lin, S.C. and Chang, M.D.T,2008,Characterization of molecular interactions between eosinophil cationic protein and heparin,Journal of Biological Chemistry,283,37,pp25468-25474 (SCI)	張大慈
2008	Chao, C.C., Sun, F.C., Wang, C.H., Lo, C.W., Chang, Y.S., Chang, K.C., Chang, M.D.T. and Lai, Y.K,2008,Concerted actions of multiple transcription elements confer differential Transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells,Journal of Cellular Biochemistry,104,4,pp1286-1296 (SCI)	張大慈
2008	Chang, S.J., Huang, T.S., Wang, K.L., Wang, T.Y., Yang, Y.C., Chang, M.D.T., Wu, Y.H. and Wang, H.W,2008,Genetic Network Analysis of Human Cd34(+) Hematopoietic Stem/Precursor Cells,Taiwanese Journal of Obstetrics & Gynecology,47,4,pp422-430 (SCI)	張大慈
2007	Wang, H.Y., Chang, H.T., Pai, T.W., Wu, C.I., Lee, Y.H., Chang, Y.H., Tai, H.L., Tang, C.Y., Chou, W.Y. and Chang, M.D.T,2007,Transcriptional regulation of human eosinophil RNases by an evolutionary-conserved sequence motif in primate genome,BMC Molecular Biology,8,pp89- (SCI)	張大慈
2007	Fan, T.C., Chang, H.T., Chen, I.W., Wang, H.Y. and Chang, M.D.T,2007,A heparan sulfate-facilitated and raft-dependent macropinocytosis of eosinophil cationic protein, Traffic,8,12,pp1778-1795 (SCI)	張大慈
2007	Tsai, C.H., Chen, C.P., Chang, M.D.T., Chang, S.J. and Chien, S.C.,2007,Hematometrocolpos secondary to didelphic uterus and unilateral imperforated double vagina as an unusal cause of acute abdomen,Taiwanese Journal of Obstetrics & Gynecology,46,4,pp448-452 (SCI)	張大慈
2007	Liu, Y.N., Lai, Y.T., Chou, W.I., Chang, M.D.T.* and Lyu, P.C,2007,Solution structure of family 21 carbohydrate-binding module from Rhizopus oryzae glucoamylase,Biochemical Journal,403,pp21-30 (SCI)	張大慈
2007	Chang, H.T., Kao, Y.L., Wu, C.M., Fan, T.C., Lai, Y.K., Huang, K.L., Chang, Y.S., Tsai, J.J. and Chang, M.D.T,2007,Signal peptide of eosinophil cationic protein upregulates transforming growth factor-alpha expression in human cells,Journal of Cellular Biochemistry,100,5,pp1266-1275 (SCI)	張大慈
2007	Lin, S.C., Liu, W.T., Liu, S.H., Hsiung, B.K., Chou, W.I., Lin, I. P., Sheu, C.C. and Chang, M.D.T.,2007,Role of the linker region in the expression of Rhizopus oryzae glucoamylase,BMC Biochemistry,8,pp9-	張大慈
2007	Huang, Y.C., Lin, Y.M., Chang, T.W., Wu, S.J., Lee, Y.S., Chang, M.D.T., Chen, C., Wu, S.H. and Liao, Y.D.,2007,The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity,Journal of Biological Chemistry,282,7,pp4626-4633 (SCI)	張大慈
2007	Wan, C.F., Chen, W.H., Chen, C.T., Chang, M.D.T., Lo, L.C. and Li, Y.K,2007,Mutagenesis and mechanistic study of a glycoside hydrolase family 54 alpha-L-arabinofuranosidase from Trichoderma koningii,Biochemical Journal,401,2,pp551-558 (SCI)	張大慈
2006	Chiou, S.H., Yang, Y.P., Lin, J.C., Hsu, C.H., Jhang, H.C., Yang, Y.T., Lee, C.H., Ho, L.L.T., Hsu, W.M., Ku, H.H., Chen, S.J., Chen, S.S.L., Chang, M.D.T., Wu, C.W. and Juan, L.J.,2006,The immediate early 2 protein of human cytomegalovirus mediates the apoptotic control in HCMV retinitis through activation of cellular FLICE-inhibitory protein,Journal of Immunology,177,9,pp6199-6206 (SCI)	張大慈
2006	Lai, C.W., Chan, Z.R., Yang, D.G., Lo, W.H., Lai, Y.K., Chang, M.D.T. and Hu, Y.C,2006,Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein,FEBS Letters,580,16,pp3829-3834 (SCI)	張大慈
2006	Chou, W.I., Pai, T.W., Liu, S.H., Hsiung, B.K. and Chang, M.D.T,2006,The family 21 carbohydrate-binding module of glucoamylase from Rhizopus oryzae consists of two sites playing distinct roles in ligand binding,Biochemical Journal ,396,3,pp469-477 (SCI)	張大慈
2006	Chang, Y.S., Lo, C.W., Sun, F.C., Chang, M.D.T. and Lai, Y.K,2006,Differential expression of Hsp90 isoforms in geldanamycin-treated 9L cells,Biochemical and Biophysical Research Communications,344,1,pp37-44 (SCI)	張大慈
2006	Chang, H.T., Pai, T.W., Fan, T.C., Su, B.H., Wu, P.C., Tang, C.Y., Chang, C.T., Liu, S.H. and Chang, M.D.T,2006,A reinforced merging methodology for mapping unique peptide motifs in members of protein families,BMC Bioinformatics,07,pp38- (SCI)	張大慈
2006	Pai, T.W., Chang, M.D.T., Tzou, W.S., Su, B.H., Wu, P.C., Chang, H.T. and Chou, W.I.,2006,REMUS: a tool for identification of unique peptide segments as epitopes,Nucleic Acids Research,34,ppW198-W201 (SCI)	張大慈
2006	Pai, T.W., Su, B.H., Wu, P.C., Chang, M.D.T., Chang, H.T., Fan, T.C. and Liu, S.H,2006,Unique Peptide Identification of RNaseA Superfamily Sequences based onReinforced Merging Algorithms,Journal of Bioinformatics and Computational Biology*,4,pp75-92	張大慈
2005	2005,Wang, K.-C., Wu, J.-C., Chung, Y.-C., Ho, Y.-C., Chang, M. D.-T., Hu, Y.-C. (2005) Baculovirus as a highly efficient gene delivery vector for the expression of hepatitis delta virus antigens in mammalian cells. Biotechnol. Bioeng. 89, 464-473. ,	張大慈
2005	2005,Liu, S.-H., Chou, W.-I., Sheu, C.-C., Chang, M. D.-T.* (2005) Improved secretory production of glucoamylase in Pichia pastoris by combination of genetic manipulations. Biochem. Biophys. Res. Commun. 326, 817-824. ,	張大慈
2005	2005,Lai, C.-W., Chung, Y.-C., Lai, Y.-K., Chang, M. D.-T., Hu, Y.-C. (2005) Expression and purification of N and E proteins from Severe Acute Respiratory Syndrome (SARS)-associated coronavirus: A comparative study. Biotechnol. Lett. 27, 883-891. ,	張大慈
2005	2005,Liu, S.-H., Chou, W.-I., Lin, S.-C., Sheu, C.-C., Chang, M. D.-T.* (2005) Molecular genetic manipulation of Pichia pastoris SEC4 governs cell growth and glucoamylase secretion. Biochem. Biophys. Res. Commun. 336:1172-1180. ,	張大慈
2004	2004,Hsu, C.-H., Chang, M. D.-T., Tai, K.-Y., Wang, P.-S., Yang, Y.-T., Chen, C.-J., Wang, Y.-H., Lee, S.-C., Wu, C.-W., Juan, L.-J. (2004) HCMV IE2-mediated inhibition of HAT activity downregulates p53 function. EMBO J. 23, 2269-2280. ,	張大慈
2004	2004,Wu, C.-M., Chang, H. –T., Chang, M. D.-T.* (2004) Membrane-bound carboxypeptidase facilitates endocytosis of eosinophil cationic protein. Biochem. J. 382, 841-848. ,	張大慈
2004	2004,Wu, C.-M., Chang, M. D.-T.* (2004) Signal peptide of eosinophil cationic protein is toxic to cells lacking signal peptide peptidase. Biochem. Biophys. Res. Commun. 322, 585-592. ,	張大慈
2004	2004,Pai, T.-W., Chu, J.-H., Chang, M. D.-T.* (2004) Internal jumping searching algorithms for bio-sequence pattern matching. J. Computers 16, 20-28. ,	張大慈
2003	2003,Tang, C.-Y., Lu, C.-L., Chang, M. D.-T., Tsai, Y.-T., Sun, Y.-J., Chao, K.-M., Chang, J.-M., Chiou, Y.-H., Wu, C.-M., Chang, H.-T., Chou, W.-I. (2003) Constrained multiple sequence alignment tool development and its application to RNase family alignment. Journal of Bioinformatics and Computational Biology 1, 267-287. ,	張大慈
2003	2003,Cheng, T.-J., Tseng, Y.-F., Chang, W.-M., Chang, M. D.-T., Lai, Y.-K. (2003) Retaining of the assembly capability of vimentin phosphorylated by mitogen-activated protein kinase-activated protein kinase-2. J. Cell. Biochem. 89, 589-602. ,	張大慈

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